White adipose tissue reference network: a knowledge resource for exploring health-relevant relations.

ABSTRACT: Optimal health is maintained by interaction of multiple intrinsic and environmental factors at different levels of complexity-from molecular, to physiological, to social. Understanding and quantification of these interactions will aid design of successful health interventions. We introduce the reference network concept as a platform for multi-level exploration of biological relations relevant for metabolic health, by integration and mining of biological interactions derived from public resources and context-specific experimental data. A White Adipose Tissue Health Reference Network (WATRefNet) was constructed as a resource for discovery and prioritization of mechanism-based biomarkers for white adipose tissue (WAT) health status and the effect of food and drug compounds on WAT health statu

SUBMITTER: Kelder T 

PROVIDER: S-EPMC4252261 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature