Simulation of complex transport of nanoparticles around a tumor using tumor-microenvironment-on-chip.

ABSTRACT: Delivery of therapeutic agents selectively to tumor tissue, which is referred as "targeted delivery," is one of the most ardently pursued goals of cancer therapy. Recent advances in nanotechnology enable numerous types of nanoparticles (NPs) whose properties can be designed for targeted delivery to tumors. In spite of promising early results, the delivery and therapeutic efficacy of the majority of NPs are still quite limited. This is mainly attributed to the limitation of currently available tumor models to test these NPs and systematically study the effects of complex transport and pathophysiological barriers around the tumors. In this study, thus, we developed a new in vitro tumor model to recapitulate the tumor microenvironment determining the transport around tumors. This model, named

SUBMITTER: Kwak B 

PROVIDER: S-EPMC4252353 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature