Exosomal miR-1290 and miR-375 as prognostic markers in castration-resistant prostate cancer.

ABSTRACT:

Background

Extracellular microRNAs (miRNAs) embedded in circulating exosomes may serves as prognostic biomarkers in cancer.

Objective

To identify and evaluate plasma exosomal miRNAs for prognosis in castration-resistant prostate cancer (CRPC).

Design, setting, and participants

RNA sequencing was performed to identify candidate exosomal miRNAs associated with overall survival in a screening cohort of 23 CRPC patients. Candidate miRNAs were further evaluated for prognosis using quantitative real-time polymerase chain reaction in a follow-up cohort of 100 CRPC patients.

Outcome measurements and statistical analysis

Cox regression and Kaplan-Meier survival analyses were used to evaluate survival association using candidate miRNAs along with clinical prognostic fact

SUBMITTER: Huang X 

PROVIDER: S-EPMC4252606 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature