Complement pathway is frequently altered in endometriosis and endometriosis-associated ovarian cancer.

ABSTRACT:

Purpose

Mechanisms of immune dysregulation associated with advanced tumors are relatively well understood. Much less is known about the role of immune effectors against cancer precursor lesions. Endometrioid and clear-cell ovarian tumors partly derive from endometriosis, a commonly diagnosed chronic inflammatory disease. We performed here a comprehensive immune gene expression analysis of pelvic inflammation in endometriosis and endometriosis-associated ovarian cancer (EAOC).

Experimental design

RNA was extracted from 120 paraffin tissue blocks comprising of normal endometrium (n = 32), benign endometriosis (n = 30), atypical endometriosis (n = 15), and EAOC (n = 43). Serous tumors (n = 15) were included as nonendometriosis-associated controls. The immune microenvironment wa

SUBMITTER: Suryawanshi S 

PROVIDER: S-EPMC4252715 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature