Macular function and morphologic features in juvenile stargardt disease: longitudinal study.

ABSTRACT:

Purpose

To evaluate disease progression in a cohort of patients with a clinical and genetic diagnosis of Stargardt disease.

Design

Longitudinal cohort study.

Participants

A total of 56 selected patients with a clinical and molecular diagnosis of Stargardt disease, an early age of onset, and a median follow-up length of 2 years.

Methods

Patients underwent routine examination, including full-field electroretinography, microperimetry, and optical coherence tomography.

Main outcome measures

Best-corrected visual acuity (BCVA), mean retinal sensitivity, fixation stability, preferred retinal locus, inner segment/outer segment (IS/OS) junction loss, and atrophic lesion area.

Results

A total of 56 patients with a mean age at disease onset of 15.3 years (r

SUBMITTER: Testa F 

PROVIDER: S-EPMC4252720 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature