A comparison of neuropsychological performance between US and Russia: preparing for a global clinical trial.

ABSTRACT:

Background

Understanding regional differences in cognitive performance is important for interpretation of data from large multinational clinical trials.

Methods

Data from Durham and Cabarrus Counties in North Carolina, USA and Tomsk, Russia (n = 2972) were evaluated. The Montreal Cognitive Assessment (MoCA), Trail Making Test Part B (Trails B), Consortium to Establish a Registry for Alzheimer's Disease Word List Memory Test (WLM) delayed recall, and self-report Alzheimer's Disease Cooperative Studies Mail-In Cognitive Function Screening Instrument (MCFSI) were administered at each site. Multilevel modeling measured the variance explained by site and predictors of cognitive performance.

Results

Site differences accounted for 11% of the variation in the MoCA, 1.6% in Tr

SUBMITTER: Hayden KM 

PROVIDER: S-EPMC4252725 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature