Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells.

ABSTRACT: Embryonic stem (ES) cells are characterized by pluripotency, defined as the developmental potential to generate cell lineages derived from all three primary germ layers. In the past decade, great progress has been made on the cell culture conditions, transcription factor programs and intracellular signaling pathways that control both murine and human ES cell fates. ES cells of mouse vs. human origin have distinct culture conditions, responding to some tyrosine kinase signaling pathways in opposite ways. Previous work has implicated the Src family of non-receptor protein-tyrosine kinases in mouse ES cell self-renewal and differentiation. Seven members of the Src kinase family are expressed in mouse ES cells, and individual family members appear to play distinct roles in regulating their dev

SUBMITTER: Zhang X 

PROVIDER: S-EPMC4252886 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature