Reduced mediodorsal thalamic volume and prefrontal cortical spindle activity in schizophrenia.

ABSTRACT:

Background

We recently found marked deficits in sleep spindles, non-rapid eye movement (NREM) sleep oscillations that are generated within the thalamus and then amplified and sustained in the cortex, in patients with schizophrenia compared to both healthy and psychiatric controls. Here, we investigated the thalamic and cortical contributions to these sleep spindle deficits.

Methods

Anatomical volume of interest analysis (i.e., thalamic volumes) and electroencephalogram (EEG) source modeling (i.e., spindle-related cortical currents) were performed in patients with schizophrenia and healthy comparison subjects.

Findings

Schizophrenia patients had reduced mediodorsal (MD) thalamic volumes, especially on the left side, compared to healthy controls, whereas whole thalami a

SUBMITTER: Buchmann A 

PROVIDER: S-EPMC4253071 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature