Outcomes of patients with advanced cancer and KRAS mutations in phase I clinical trials.

ABSTRACT:

Background

KRAS mutation is common in human cancer. We assessed the clinical factors, including type of KRAS mutation and treatment, of patients with advanced cancer and tumor KRAS mutations and their association with treatment outcomes.

Methods

Patients referred to the Phase I Clinic for treatment who underwent testing for KRAS mutations were analyzed.

Results

Of 1,781 patients, 365 (21%) had a KRAS mutation. The G12D mutation was the most common mutation (29%). PIK3CA mutations were found in 24% and 10% of patients with and without KRAS mutations (p<0.0001). Of 223 patients with a KRAS mutation who were evaluable for response, 56 were treated with a MEK inhibitor-containing therapy and 167 with other therapies. The clinical benefit (partial response and stable disea

SUBMITTER: Said R 

PROVIDER: S-EPMC4253408 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature