Ontology highlight
ABSTRACT:
SUBMITTER: Fang ZP
PROVIDER: S-EPMC4253432 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Oncotarget 20141001 19
The expression of RNA polymerase II subunit 3 (Rpb3) was found frequent up-regulation in Hepatocellular carcinoma (HCC) tumors. Significant associations could also be drawn between increased expressions of Rpb3 and advance HCC staging and shorter disease-free survival of patients. Overexpression of Rpb3 increased HCC cell proliferation, migratory rate and tumor growth in nude mice, whereas suppression of Rpb3 using shRNA inhibited these effects. For mechanism study, we found that Rpb3 bound dire ...[more]