Ontology highlight
ABSTRACT:
SUBMITTER: Kim AD
PROVIDER: S-EPMC4253525 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Kim Albert D AD Melick Chase H CH Clements Wilson K WK Stachura David L DL Distel Martin M Panáková Daniela D MacRae Calum C Mork Lindsey A LA Crump J Gage JG Traver David D
The EMBO journal 20140917 20
Hematopoietic stem cells (HSCs) require multiple molecular inputs for proper specification, including activity of the Notch signaling pathway. A requirement for the Notch1 and dispensability of the Notch2 receptor has been demonstrated in mice, but the role of the remaining Notch receptors has not been investigated. Here, we demonstrate that three of the four Notch receptors are independently required for the specification of HSCs in the zebrafish. The orthologues of the murine Notch1 receptor, ...[more]