Characterization of HIV-1 envelopes in acutely and chronically infected injection drug users.

ABSTRACT:

Background

Mucosally acquired human immunodeficiency virus type 1 (HIV-1) infection results from a limited number of variants, and these infecting strains potentially have unique properties, such as increased susceptibility to entry blockers, relative interferon-alpha (IFN-α) resistance, and replication differences in some primary cells. There is no data about the phenotypic properties of HIV-1 envelope variants found early after acquisition among subjects infected through injection drug use (IDU). For the first time, we compared the characteristics of virus envelopes among injection drug users sampled prior to seroconversion (HIV RNA+/Ab-), within 1 year (early), and more than 2 years (chronic) after estimated acquisition.

Results

Virus envelopes from 7 HIV RNA+/Ab- subject

SUBMITTER: Etemad B 

PROVIDER: S-EPMC4253609 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature