Neural systems for cognitive reappraisal in children and adolescents with autism spectrum disorder.

ABSTRACT: Despite substantial clinical and anecdotal evidence for emotion dysregulation in individuals with autism spectrum disorder (ASD), little is known about the neural substrates underlying this phenomenon. We sought to explore neural mechanisms for cognitive reappraisal in children and adolescents with ASD using functional magnetic resonance imaging (fMRI). We studied 16 youth with ASD and 15 age- and IQ-matched typically developing (TD) comparison youth. Participants were instructed in the use of cognitive reappraisal strategies to increase and decrease their emotional responses to disgusting images. Participants in both groups displayed distinct patterns of brain activity for increasing versus decreasing their emotions. TD participants showed downregulation of bilateral insula and left amygd

SUBMITTER: Pitskel NB 

PROVIDER: S-EPMC4253669 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature