The effect of modified ultrafiltration on angiopoietins in pediatric cardiothoracic operations.

ABSTRACT:

Background

Cardiopulmonary bypass subjects patients' blood to hemodilution and nonphysiologic conditions, resulting in a systemic inflammatory response. Modified ultrafiltration (MUF) counteracts hemodilution and has also been postulated to improve outcomes by proinflammatory cytokine removal. The objective of this study was to investigate whether the benefits of MUF include the removal of proinflammatory mediators, such as angiopoietin-2 (angpt-2). We hypothesize that some of the clinical benefits of MUF are related to the preferential removal of angpt-2.

Methods

We performed a prospective cohort study in children 18 years old or younger undergoing cardiopulmonary bypass. Serum samples were obtained from each patient preoperatively, after cardiopulmonary bypass, and on inte

SUBMITTER: Lang SM 

PROVIDER: S-EPMC4253712 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature