CD47 in the tumor microenvironment limits cooperation between antitumor T-cell immunity and radiotherapy.

ABSTRACT: Although significant advances in radiotherapy have increased its effectiveness in many cancer settings, general strategies to widen the therapeutic window between normal tissue toxicity and malignant tumor destruction would still offer great value. CD47 blockade has been found to confer radioprotection to normal tissues while enhancing tumor radiosensitivity. Here, we report that CD47 blockade directly enhances tumor immunosurveillance by CD8(+) T cells. Combining CD47 blockade with irradiation did not affect fibrosarcoma growth in T cell-deficient mice, whereas adoptive transfer of tumor-specific CD8(+) T cells restored combinatorial efficacy. Furthermore, ablation of CD8(+) T cells abolished radiotherapeutic response in immunocompetent syngeneic hosts. CD47 blockade in either target cell

SUBMITTER: Soto-Pantoja DR 

PROVIDER: S-EPMC4253868 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature