A genome-wide survey of CD4(+) lymphocyte regulatory genetic variants identifies novel asthma genes.

ABSTRACT:

Background

Genome-wide association studies have yet to identify the majority of genetic variants involved in asthma. We hypothesized that expression quantitative trait locus (eQTL) mapping can identify novel asthma genes by enabling prioritization of putative functional variants for association testing.

Objective

We evaluated 6706 cis-acting expression-associated variants (eSNPs) identified through a genome-wide eQTL survey of CD4(+) lymphocytes for association with asthma.

Methods

eSNPs were tested for association with asthma in 359 asthmatic patients and 846 control subjects from the Childhood Asthma Management Program, with verification by using family-based testing. Significant associations were tested for replication in 579 parent-child trios with asthma from Cos

SUBMITTER: Sharma S 

PROVIDER: S-EPMC4253878 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature