Stem cell transplantation as a dynamical system: are clinical outcomes deterministic?

ABSTRACT: Outcomes in stem cell transplantation (SCT) are modeled using probability theory. However, the clinical course following SCT appears to demonstrate many characteristics of dynamical systems, especially when outcomes are considered in the context of immune reconstitution. Dynamical systems tend to evolve over time according to mathematically determined rules. Characteristically, the future states of the system are predicated on the states preceding them, and there is sensitivity to initial conditions. In SCT, the interaction between donor T cells and the recipient may be considered as such a system in which, graft source, conditioning, and early immunosuppression profoundly influence immune reconstitution over time. This eventually determines clinical outcomes, either the emergence of toler

SUBMITTER: Toor AA 

PROVIDER: S-EPMC4253954 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature