Is maternal smoking during pregnancy associated with bipolar disorder in offspring?

ABSTRACT:

Background

Prenatal smoking exposure affects fetal growth and development and is associated with increased risk of various neurodevelopmental disorders. Only one previous study has examined the association between maternal smoking during pregnancy and the risk of bipolar disorder (BPD).

Methods

In this nested case control study derived from all singleton live births in Finland between January 1st 1987 and December 31st 1998, we identified 724 children diagnosed and/or treated with BPD until 2008 and 1419 matched controls from four nationwide registers. Conditional logistic regression was used to examine the association between maternal smoking during pregnancy and BPD adjusting for potential confounding due to parental psychiatric history, maternal age and education level.

SUBMITTER: Chudal R 

PROVIDER: S-EPMC4253972 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature