Amygdala enlargement in unaffected offspring of bipolar parents.

ABSTRACT:

Background

Bipolar disorder (BD) is a devastating disorder with a strong genetic component. While the frontolimbic profile of individuals suffering from BD is relatively well-established, there is still disagreement over the neuroanatomical features of unaffected BD offspring.

Material and methods

Brain volumetric measures were obtained for 82 children and adolescents including 18 unaffected BD offspring (10.50 ± 3.37 years), 19 BD offspring suffering from psychiatric disorders (12.87 ± 3.28 years) and 45 healthy controls (HC-10.50 ± 3.37 years). Clinical diagnoses were established according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria. Cortical reconstruction and volumetric segmentation were performed with the Freesurfer image analysis suit

SUBMITTER: Bauer IE 

PROVIDER: S-EPMC4254042 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature