Ibuprofen supplementation and its effects on NF-κB activation in skeletal muscle following resistance exercise.

ABSTRACT: Resistance exercise triggers a subclinical inflammatory response that plays a pivotal role in skeletal muscle regeneration. Nuclear factor-κB (NF-κB) is a stress signalling transcription factor that regulates acute and chronic states of inflammation. The classical NF-κB pathway regulates the early activation of post-exercise inflammation; however there remains scope for this complex transcription factor to play a more detailed role in post-exercise muscle recovery. Sixteen volunteers completed a bout of lower body resistance exercise with the ingestion of three 400 mg doses of ibuprofen or a placebo control. Muscle biopsy samples were obtained prior to exercise and at 0, 3 and 24 h post-exercise and analysed for key markers of NF-κB activity. Phosphorylated p65 protein expression and p65 i

SUBMITTER: Vella L 

PROVIDER: S-EPMC4254097 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature