Improved measurement of brain deformation during mild head acceleration using a novel tagged MRI sequence.

ABSTRACT: In vivo measurements of human brain deformation during mild acceleration are needed to help validate computational models of traumatic brain injury and to understand the factors that govern the mechanical response of the brain. Tagged magnetic resonance imaging is a powerful, noninvasive technique to track tissue motion in vivo which has been used to quantify brain deformation in live human subjects. However, these prior studies required from 72 to 144 head rotations to generate deformation data for a single image slice, precluding its use to investigate the entire brain in a single subject. Here, a novel method is introduced that significantly reduces temporal variability in the acquisition and improves the accuracy of displacement estimates. Optimization of the acquisition parameters in

SUBMITTER: Knutsen AK 

PROVIDER: S-EPMC4254110 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature