Symptom trajectories and psychosis onset in a clinical high-risk cohort: the relevance of subthreshold thought disorder.

ABSTRACT:

Background

Prior studies have implicated baseline positive and negative symptoms as predictors of psychosis onset among individuals at clinical high risk (CHR), but none have evaluated latent trajectories of symptoms over time. This study evaluated the dynamic evolution of symptoms leading to psychosis onset in a CHR cohort.

Method

100 CHR participants were assessed quarterly for up to 2.5 years. Latent trajectory analysis was used to identify patterns of symptom change. Logistic and proportional hazards models were employed to evaluate the predictive value for psychosis onset of baseline symptoms and symptom trajectories.

Results

Transition rate to psychosis was 26%. Disorganized communication (i.e., subthreshold thought disorder) presented an increased hazard for ps

SUBMITTER: DeVylder JE 

PROVIDER: S-EPMC4254175 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature