Maternal obesity and gestational diabetes are associated with placental leptin DNA methylation.

ABSTRACT:

Objective

In this study, we aimed to investigate relationships between maternal prepregnancy obesity and gestational diabetes mellitus and placental leptin DNA methylation.

Study design

This study comprises data on 535 mother-infant dyads enrolled in the Rhode Island Child Health Study, a prospective cohort study of healthy term pregnancies. Prepregnancy body mass index was calculated from self-reported anthropometric measures and gestational diabetes mellitus diagnoses gathered from inpatient medical records. DNA methylation of the leptin promoter region was assessed in placental tissue collected at birth using quantitative bisulfite pyrosequencing.

Results

In a multivariable regression analysis adjusted for confounders, infants exposed to gestational diabetes mellit

SUBMITTER: Lesseur C 

PROVIDER: S-EPMC4254188 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature