Suppression of histone deacetylation promotes the differentiation of human pluripotent stem cells towards neural progenitor cells.

ABSTRACT:

Background

Emerging studies of human pluripotent stem cells (hPSCs) raise new prospects for neurodegenerative disease modeling and cell replacement therapies. Therefore, understanding the mechanisms underlying the commitment of neural progenitor cells (NPCs) is important for the application of hPSCs in neurodegenerative disease therapies. It has been reported that epigenetic modifications of histones play important roles in neural differentiation, but the exact mechanisms in regulating hPSC differentiation towards NPCs are not fully elucidated.

Results

We demonstrated that suppression of histone deacetylases (HDACs) promoted the differentiation of hPSCs towards NPCs. Application of HDAC inhibitors (HDACi) increased the expression of neuroectodermal markers and enhanced the n

SUBMITTER: Yang J 

PROVIDER: S-EPMC4254204 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature