Risk factors for cardiovascular disease across the spectrum of older age: the Cardiovascular Health Study.

ABSTRACT:

Objective

The associations of some risk factors with cardiovascular disease (CVD) are attenuated in older age; whereas others appear robust. The present study aimed to compare CVD risk factors across older age.

Methods

Participants (n = 4883) in the Cardiovascular Health Study free of prevalent CVD, were stratified into three age groups: 65-74, 75-84, 85+ years. Traditional risk factors included systolic blood pressure (BP), LDL-cholesterol, HDL-cholesterol, obesity, and diabetes. Novel risk factors included kidney function, C-reactive protein (CRP), and N-terminal pro-B-type natriuretic peptide (NT pro-BNP).

Results

There were 1498 composite CVD events (stroke, myocardial infarction, and cardiovascular death) over 5 years. The associations of high systolic BP and dia

SUBMITTER: Odden MC 

PROVIDER: S-EPMC4254262 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature