Associations between red cell polymorphisms and Plasmodium falciparum infection in the middle belt of Ghana.

ABSTRACT:

Background

Red blood cell (RBC) polymorphisms are common in malaria endemic regions and are known to protect against severe forms of the disease. Therefore, it is important to screen for these polymorphisms in drugs or vaccines efficacy trials. This study was undertaken to evaluate associations between clinical malaria and RBC polymorphisms to assess biological interactions that may be necessary for consideration when designing clinical trials.

Method

In a cross-sectional study of 341 febrile children less than five years of age, associations between clinical malaria and common RBC polymorphisms including the sickle cell gene and G6PD deficiency was evaluated between November 2008 and June 2009 in the middle belt of Ghana, Kintampo. G6PD deficiency was determined by quantita

SUBMITTER: Amoako N 

PROVIDER: S-EPMC4254276 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature