Histologic eosinophilic gastritis is a systemic disorder associated with blood and extragastric eosinophilia, TH2 immunity, and a unique gastric transcriptome.

ABSTRACT:

Background

The definition of eosinophilic gastritis (EG) is currently limited to histologic EG based on the tissue eosinophil count.

Objective

We aimed to provide additional fundamental information about the molecular, histopathologic, and clinical characteristics of EG.

Methods

Genome-wide transcript profiles and histologic features of gastric biopsy specimens, as well as blood eosinophil counts, were analyzed in patients with EG and control subjects (n = 15 each).

Results

The peak gastric antrum eosinophil count was 283 ± 164 eosinophils/×400 high-power field in patients with EG and 11 ± 9 eosinophils/×400 high-power field in control subjects (P = 6.1 × 10(-7)). Patients with EG (87%) had coexisting eosinophilic inflammation in multiple gastrointestinal segme

SUBMITTER: Caldwell JM 

PROVIDER: S-EPMC4254306 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature