Pediatric intestinal failure-associated liver disease is reversed with 6 months of intravenous fish oil.

ABSTRACT:

Background

Studies have suggested that when intravenous (IV) soybean oil (SO) is replaced with fish oil (FO), direct hyperbilirubinemia is more likely to resolve. The necessary duration of FO has not been established. This study seeks to determine if 24 weeks of FO is an effective and safe therapy for intestinal failure-associated liver disease (IFALD).

Materials and methods

This is a clinical trial using patients with IFALD between the ages of 2 weeks and 18 years. SO was replaced with FO (1 g/kg/d) in 10 patients who were receiving most of their calories from parenteral nutrition (PN). Patients were compared with 20 historic controls receiving SO. SO for both groups was prescribed by the primary medical team at variable doses. The primary outcome was time to reversal of ch

SUBMITTER: Calkins KL 

PROVIDER: S-EPMC4254367 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature