Mouse cytomegalovirus infection overrules T regulatory cell suppression on natural killer cells.

ABSTRACT:

Background

Cytomegalovirus establishes lifelong persistency in the host and leads to life threatening situations in immunocompromised patients. FoxP3+ T regulatory cells (Tregs) critically control and suppress innate and adaptive immune responses. However, their specific role during MCMV infection, especially pertaining to their interaction with NK cells, remains incompletely defined.

Methods

To understand the contribution of Tregs on NK cell function during acute MCMV infection, we infected Treg depleted and undepleted DEREG mice with WT MCMV and examined Treg and NK cell frequency, number, activation and effector function in vivo.

Results

Our results reveal an increased frequency of activated Tregs within the CD4+ T cell population shortly after MCMV infection. Spec

SUBMITTER: Lindenberg M 

PROVIDER: S-EPMC4254395 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature