Relationship between kidney disease and endothelial function in peripheral artery disease.

ABSTRACT:

Objective

We have previously shown that peripheral artery disease (PAD) is associated with marked impairment of endothelial function (EF). Given that poor EF is associated with functional status of PAD patients as well as with increased morbidity and mortality in patients undergoing vascular procedures, determination of factors associated with poor EF in a PAD cohort is important. We hypothesized that decreased kidney function is associated with impaired EF in patients with PAD.

Methods

This was a cross-sectional study of PAD patients presenting to a vascular surgery outpatient clinic at the San Francisco Veterans Affairs Medical Center including patients enrolled in the OMEGA-PAD I trial (NCT01310270) and the OMEGA-PAD Cohort. Brachial artery flow-mediated vasodilation was

SUBMITTER: Chong KC 

PROVIDER: S-EPMC4254442 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature