Comparative profile of cutaneous adverse events: BRAF/MEK inhibitor combination therapy versus BRAF monotherapy in melanoma.

ABSTRACT:

Background

BRAF inhibitor (BRAFi) and MEK inhibitor (MEKi) frequently cause cutaneous adverse events.

Objective

We sought to investigate the cutaneous safety profile of BRAFi versus BRAFi and MEKi combination regimens.

Methods

We performed a retrospective cohort study, collecting data from 44 patients with melanoma treated either with BRAFi (vemurafenib or dabrafenib) or BRAFi and MEKi combination regimens (vemurafenib + cobimetinib or dabrafenib + trametinib). Patient characteristics, and the occurrence and severity of cutaneous adverse events, are described.

Results

The development of cutaneous adverse events was significantly less frequent (P = .012) and occurred after longer treatment time (P = .025) in patients treated with BRAFi and MEKi combination regim

SUBMITTER: Sanlorenzo M 

PROVIDER: S-EPMC4254519 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature