Ontology highlight
ABSTRACT:
SUBMITTER: Tiedemann RL
PROVIDER: S-EPMC4254561 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Cell reports 20141106 4
Global patterns of DNA methylation, mediated by the DNA methyltransferases (DNMTs), are disrupted in all cancers by mechanisms that remain largely unknown, hampering their development as therapeutic targets. Combinatorial acute depletion of all DNMTs in a pluripotent human tumor cell line, followed by epigenome and transcriptome analysis, revealed DNMT functions in fine detail. DNMT3B occupancy regulates methylation during differentiation, whereas an unexpected interplay was discovered in which ...[more]