Optimum predictors of childhood asthma: persistent wheeze or the Asthma Predictive Index?

ABSTRACT:

Background

The Asthma Predictive Index (API) and persistent wheezing phenotypes are associated with childhood asthma, but previous studies have not assessed their ability to predict objectively confirmed asthma.

Objective

To determine whether the University of Cincinnati API Index (ucAPI) and/or persistent wheezing at age 3 can accurately predict objectively confirmed asthma at age 7.

Methods

Data from the Cincinnati Childhood Allergy and Air Pollution Study, a high-risk prospective birth cohort, was used. Asthma was defined as parent-reported or physician-diagnosed asthma objectively confirmed by a change in FEV1 of ≥12% after bronchodilator or a positive methacholine challenge (PC20 ≤ 4 mg/mL); or as prior treatment with daily asthma controller medication(s). Multiv

SUBMITTER: Amin P 

PROVIDER: S-EPMC4254628 | biostudies-literature | 2014 Nov-Dec

REPOSITORIES: biostudies-literature