Ethnic and genetic factors in methadone pharmacokinetics: a population pharmacokinetic study.

ABSTRACT:

Background

Treatment of opiate use disorders with methadone is complicated by wide interindividual variability in pharmacokinetics. To identify potentially contributing covariates in methadone pharmacokinetics, we used population pharmacokinetic modeling to estimate clearance (CL/F) and volume of distribution (V/F) for each methadone enantiomer in an ethnically diverse methadone maintained population.

Methods

Plasma levels of the opiate-active R-methadone and opiate-inactive S-methadone were measured in 206 methadone maintained subjects approximately two and twenty-three hours after a daily oral dose of rac-methadone. A linear one-compartment population pharmacokinetic model with first-order conditional estimation with interaction (FOCE-I) was used to evaluate methadone CL/F

SUBMITTER: Bart G 

PROVIDER: S-EPMC4254688 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature