Ontology highlight
ABSTRACT:
SUBMITTER: Lee AY
PROVIDER: S-EPMC4254748 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20140401 6180
Genome-wide characterization of the in vivo cellular response to perturbation is fundamental to understanding how cells survive stress. Identifying the proteins and pathways perturbed by small molecules affects biology and medicine by revealing the mechanisms of drug action. We used a yeast chemogenomics platform that quantifies the requirement for each gene for resistance to a compound in vivo to profile 3250 small molecules in a systematic and unbiased manner. We identified 317 compounds that ...[more]