18-month predictors of later outcomes in younger siblings of children with autism spectrum disorder: a baby siblings research consortium study.

ABSTRACT:

Objective

Younger siblings of children with autism spectrum disorder (ASD) are at high risk (HR) for developing ASD as well as features of the broader autism phenotype. Although this complicates early diagnostic considerations in this cohort, it also provides an opportunity to examine patterns of behavior associated specifically with ASD compared to other developmental outcomes.

Method

We applied Classification and Regression Trees (CART) analysis to individual items of the Autism Diagnostic Observation Schedule (ADOS) in 719 HR siblings to identify behavioral features at 18 months that were predictive of diagnostic outcomes (ASD, atypical development, and typical development) at 36 months.

Results

Three distinct combinations of features at 18 months were predictive o

SUBMITTER: Chawarska K 

PROVIDER: S-EPMC4254798 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature