Reassessment of omalizumab-dosing strategies and pharmacodynamics in inner-city children and adolescents.

ABSTRACT:

Background

Treatment regimens for omalizumab are guided by a dosing table that is based on total serum IgE and body weight. Limited data exist about onset and offset of omalizumab efficacy in children and adolescents or subgroups that most benefit from treatment.

Objectives

Post hoc analyses were conducted to (1) examine patient characteristics of those eligible and ineligible for omalizumab, (2) describe onset of effect after initiation of omalizumab and offset of treatment effect after stopping therapy, and (3) determine whether the efficacy differs by age, asthma severity, dosing regimen, and prespecified biomarkers.

Methods

Inner-city children and adolescents with persistent allergic asthma were enrolled in the Inner-City Anti-IgE Therapy for Asthma trial that com

SUBMITTER: Sorkness CA 

PROVIDER: S-EPMC4254887 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature