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Antiviral interferon-beta signaling induced by designed transcription activator-like effectors (TALE).

ABSTRACT: Here we show that designed transcription activator-like effectors (TALEs) that bind to defined areas of the interferon beta promoter are capable to induce IFN-beta expression and signaling in human cells. Importantly, TALE-mediated IFN-beta signaling occurs independently of pathogen pattern recognition but effectively prohibits viral RNA replication as demonstrated with a hepatitis C virus replicon. TALEs were thus indicated to be valuable tools in various applications addressing, for example, virus-host interactions.

SUBMITTER: Renner I 

PROVIDER: S-EPMC4255017 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Antiviral interferon-beta signaling induced by designed transcription activator-like effectors (TALE).

Renner Ivonne I   Funk Nancy N   Geissler Rene R   Friedrich Susann S   Penzel Anika A   Behrens Sven-Erik SE  

PloS one 20141203 12

Here we show that designed transcription activator-like effectors (TALEs) that bind to defined areas of the interferon beta promoter are capable to induce IFN-beta expression and signaling in human cells. Importantly, TALE-mediated IFN-beta signaling occurs independently of pathogen pattern recognition but effectively prohibits viral RNA replication as demonstrated with a hepatitis C virus replicon. TALEs were thus indicated to be valuable tools in various applications addressing, for example, v  ...[more]

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