The impact of aminated surface ligands and silica shells on the stability, uptake, and toxicity of engineered silver nanoparticles.

ABSTRACT: Inherent nanomaterial characteristics, composition, surface chemistry, and primary particle size, are known to impact particle stability, uptake, and toxicity. Nanocomposites challenge our ability to predict nanoparticle reactivity in biological systems if they are composed of materials with contrasting relative toxicities. We hypothesized that toxicity would be dominated by the nanoparticle surface (shell vs core), and that modulating the surface ligands would have a direct impact on uptake. We exposed developing zebrafish (Danio rerio) to a series of ~70 nm amine-terminated silver nanoparticles with silica shells (AgSi NPs) to investigate the relative influence of surface amination, composition, and size on toxicity. Like-sized aminated AgSi and Si NPs were more toxic than paired

SUBMITTER: Bonventre JA 

PROVIDER: S-EPMC4255064 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature