Overweight/Obese adults with pituitary disorders require lower peak growth hormone cutoff values on glucagon stimulation testing to avoid overdiagnosis of growth hormone deficiency.

ABSTRACT:

Context

Obesity is associated with diminished GH secretion, which may result in the overdiagnosis of adult GH deficiency (GHD) in overweight/obese pituitary patients. However, there are no body mass index (BMI)-specific peak GH cutoffs for the glucagon stimulation test (GST), the favored dynamic test for assessing adult GHD in the United States.

Objective

The objective of the study was to determine a peak GH cutoff level for the diagnosis of adult GHD in overweight/obese individuals using the GST.

Design

This was a retrospective, cross-sectional study.

Setting

The study was conducted at Massachusetts General Hospital and Oregon Health and Science University.

Methods

A total of 108 subjects with a BMI ≥ 25 kg/m(2) were studied: healthy controls (n = 47),

SUBMITTER: Dichtel LE 

PROVIDER: S-EPMC4255132 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature