Self-organizing actomyosin patterns on the cell cortex at epithelial cell-cell junctions.

ABSTRACT: The behavior of actomyosin critically determines morphologically distinct patterns of contractility found at the interface between adherent cells. One such pattern is found at the apical region (zonula adherens) of cell-cell junctions in epithelia, where clusters of the adhesion molecule E-cadherin concentrate in a static pattern. Meanwhile, E-cadherin clusters throughout lateral cell-cell contacts display dynamic movements in the plane of the junctions. To gain insight into the principles that determine the nature and organization of these dynamic structures, we analyze this behavior by modeling the 2D actomyosin cell cortex as an active fluid medium. The numerical simulations show that the stability of the actin filaments influences the spatial structure and dynamics of the system. We fi

SUBMITTER: Moore T 

PROVIDER: S-EPMC4255218 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature