Treatment effects in multiple cognitive domains in Alzheimer's disease: a two-year cohort study.

ABSTRACT:

Introduction

Despite widespread use of second-generation cholinesterase inhibitors for the symptomatic treatment of Alzheimer's disease (AD), little is known about the long term effects of cholinergic treatment on global cognitive function and potential specific effects in different cognitive domains. The objectives of this study were to determine the association between cholinergic treatment and global cognitive function over one and two years in a cohort of patients with mild or moderate AD and identify potential differences in domain-specific cognitive outcomes within this cohort.

Methods

A cohort of patients meeting the revised National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-A

SUBMITTER: Behl P 

PROVIDER: S-EPMC4255390 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature