Risk of fracture in urolithiasis: a population-based cohort study using the health improvement network.

ABSTRACT:

Background and objectives

Studies have shown decreased bone mineral density in individuals with urolithiasis, but their burden of fracture remains unclear. This study sought to determine whether urolithiasis is associated with increased fracture risk across the lifespan and to delineate sex effects.

Design, setting, participants, & measurements

A population-based retrospective cohort study using The Health Improvement Network was performed. The median calendar year for the start of the observation period was 2004 (1994-2012). This study identified 51,785 participants with ≥1 of 87 diagnostic codes for urolithiasis and 517,267 randomly selected age-, sex-, and practice-matched participants. Cox regression was used to estimate the hazard ratio (HR) for first fracture. Fracture

SUBMITTER: Denburg MR 

PROVIDER: S-EPMC4255404 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature