A MATLAB tool for pathway enrichment using a topology-based pathway regulation score.

ABSTRACT:

Background

Handling the vast amount of gene expression data generated by genome-wide transcriptional profiling techniques is a challenging task, demanding an informed combination of pre-processing, filtering and analysis methods if meaningful biological conclusions are to be drawn. For example, a range of traditional statistical and computational pathway analysis approaches have been used to identify over-represented processes in microarray data derived from various disease states. However, most of these approaches tend not to exploit the full spectrum of gene expression data, or the various relationships and dependencies. Previously, we described a pathway enrichment analysis tool created in MATLAB that yields a Pathway Regulation Score (PRS) by considering signalling pathway topo

SUBMITTER: Ibrahim M 

PROVIDER: S-EPMC4255424 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature