Which is the best postoperative chemotherapy regimen in patients with rectal cancer after neoadjuvant therapy?

ABSTRACT:

Background

There is no general agreement about whether patients who have already received neoadjuvant chemoradiotherapy need further postoperative chemotherapy based on 5-fluorouracil(5-FU) or 5-FU plus oxaliplatin.

Methods

Medicare beneficiaries from 1992 to 2008 with Union for International Cancer Control ypStages I to III primary carcinoma of the rectum who underwent 5-FU-based neoadjuvant chemoradiotherapy and surgery for curative intent were identified through the Surveillance, Epidemiology, and End Results (SEER)-Medicare-linked database. A Cox proportional hazards model and propensity score-matched techniques were used to evaluate the effect of treatment on survival.

Results

For patients with resected rectal cancer who have already received 5-FU-based neoadjuva

SUBMITTER: Gao P 

PROVIDER: S-EPMC4255436 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature