Association between cell-bound blood amyloid-β(1-40) levels and hippocampus volume.

ABSTRACT:

Introduction

The identification of early, preferably presymptomatic, biomarkers and true etiologic factors for Alzheimer's disease (AD) is the first step toward establishing effective primary and secondary prevention programs. Consequently, the search for a relatively inexpensive and harmless biomarker for AD continues. Despite intensive research worldwide, to date there is no definitive plasma or blood biomarker indicating high or low risk of conversion to AD.

Methods

Magnetic resonance imaging and β-amyloid (Aβ) levels in three blood compartments (diluted in plasma, undiluted in plasma and cell-bound) were measured in 96 subjects (33 with mild cognitive impairment, 14 with AD and 49 healthy controls). Pearson correlations were completed between 113 regions of interest (ROI

SUBMITTER: Sotolongo-Grau O 

PROVIDER: S-EPMC4255526 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature