An ensemble of aptamers and antibodies for multivalent capture of cancer cells.

ABSTRACT: We developed an optimized ensemble of aptamers and antibodies that functions as a multivalent adhesive domain for the capture and isolation of cancer cells. When incorporated into a microfluidic device, the ensemble showed not only high capture efficiency, but also superior capture selectivity at a high shear stress (or high flow rate).

SUBMITTER: Zhang J 

PROVIDER: S-EPMC4255561 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature