Ontology highlight
ABSTRACT:
SUBMITTER: Woodard CM
PROVIDER: S-EPMC4255586 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Cell reports 20141106 4
Parkinson's disease (PD) has been attributed to a combination of genetic and nongenetic factors. We studied a set of monozygotic twins harboring the heterozygous glucocerebrosidase mutation (GBA N370S) but clinically discordant for PD. We applied induced pluripotent stem cell (iPSC) technology for PD disease modeling using the twins' fibroblasts to evaluate and dissect the genetic and nongenetic contributions. Utilizing fluorescence-activated cell sorting, we obtained a homogenous population of ...[more]