Multilayer thin film coatings capable of extended programmable drug release: application to human mesenchymal stem cell differentiation.

ABSTRACT: The promise of cellular therapy lies in healing damaged tissues and organs in vivo as well as generating tissue constructs in vitro for subsequent transplantation. Adult stem cells are ideally suited for cellular therapies due to their pulripotency and the ease with which they can be cultured on novel functionalized substrates. Creating environments to control and successively driving their differentiation toward a lineage of choice is one of the most important challenges of current cell-based engineering strategies. In recent years, a variety of biomedical platforms have been prepared for stem cell cultures, primarily to provide efficient delivery of growth or survival factors to cells and a conducive microenvironment for their growth. Here, we demonstrate that repeating tetralayer struct

SUBMITTER: Hong J 

PROVIDER: S-EPMC4255723 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature