Fragment-based screening of the bromodomain of ATAD2.

ABSTRACT: Cellular and genetic evidence suggest that inhibition of ATAD2 could be a useful strategy to treat several types of cancer. To discover small-molecule inhibitors of the bromodomain of ATAD2, we used a fragment-based approach. Fragment hits were identified using NMR spectroscopy, and ATAD2 was crystallized with three of the hits identified in the fragment screen.

SUBMITTER: Harner MJ 

PROVIDER: S-EPMC4255743 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature